Immunization of mice against West Nile virus with recombinant envelope protein.

Protective and therapeutic capacity of human single-chain Fv-Fc fusion proteins against West Nile virus.

West Nile virus has spread rapidly across the United States, and there is currently no approved human vaccine or therapy to prevent or treat disease. Passive immunization with antibodies against the envelope protein represents a promising means to provide short-term prophylaxis and treatment for West Nile virus infection. In this study, we identified a panel of 11 unique human single-chain vari...

Dengue virus type-3 envelope protein domain III; expression and immunogenicity

Objective(s): Production of a recombinant and immunogenic antigen using dengue virus type-3 envelope protein is a key point in dengue vaccine development and diagnostic researches. The goals of this study were providing a recombinant protein from dengue virus type-3 envelope protein and evaluation of its immunogenicity in mice. Materials and Methods: Multiple amino acid sequences of different i...

Protection against West Nile Virus Infection Induced Specific Immune Response and Recombinant Envelope Domain III Protein Immunization of Flavivirus West Nile

Correction: Vaccination of Mice Using the West Nile Virus E-Protein in a DNA Prime-Protein Boost Strategy Stimulates Cell-Mediated Immunity and Protects Mice against a Lethal Challenge

The last sentence of the ‘‘WNV DNA Vaccine, Control Plasmid and E-protein’’ section of the Materials and Methods should read: ‘‘For protein booster vaccine formulation the E-protein was adjuvanted with 10 mg Matrix-M1 adjuvant (Novavax AB, Uppsala, Sweden).’’ In addition, the following sentence should be inserted as the last sentence of the ‘‘Vaccination Procedures’’ section of the Materials an...

Effect of IL-2 co-expressed or co-inoculated with immuno-dominant epitopes from VP1 protein of FMD virus on immune responses in BALB/c mice

Objective(s): The results of studies on vaccine development for foot-and-mouth disease (FMD) virus show that the use of inactivated vaccines for FMD virus is not completely effective. Novel vaccinations based on immuno-dominant epitopes have been shown to induce immune responses. Furthermore, for safety of immunization, access to efficient adjuvants against FMD virus seems to be critical.Materi...